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Updated: Sep 2, 2026
Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Transcatheter thrombolysis in children with Takayasu's arteritis complicated by acute cerebral infarction: a case
Li-Shan Ding1, Hao Liang2, Ming Zheng2
1Department of Hemato-Oncology, The First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450099, Henan, China.
Background:
Takayasu arteritis (TA), a rare systemic macrovasculitis in children, affects multiple arteries, causing necrosis, remodeling, stenosis, or dilatation. Due to nonspecific symptoms, early diagnosis is challenging, and it is often missed until organ dysfunction occurs. TA poses a significant health threat, with few reports on acute cerebral infarction in pediatric cases.
Case Presentation:
An 11-year-old girl presented with TA-induced thrombosis in the right middle cerebral artery's upper trunk. Despite prompt thrombolysis restoring blood flow, brain tissue necrosis and dysfunction persisted. Pre-intervention MRA showed occlusion and stenosis in relevant arteries. Subsequent angiography confirmed multiple-artery acute stroke, supported by imaging, serology, and cerebrospinal fluid tests. Timely rehabilitation, hormone treatment, and early diagnosis led to a favorable outcome.
Conclusions:
Early diagnosis and treatment of pediatric TA are crucial to prevent organ damage. Transcatheter thrombolysis effectively restores brain perfusion in acute infarction cases.
