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Updated: Jun 5, 2025
Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Published on: February 29, 2020
A novel multilayered membrane repair technique for high-flow cerebrospinal fluid leaks during expanded endoscopic
Chuan Shao1,2, Junwei Wang1, Pan Wang1
1Department of Neurosurgery, Chongqing General Hospital, Chongqing University Chongqing 401147, China.
Background:
Postoperative cerebrospinal fluid (CSF) leak is a life-threatening complication following endoscopic skull base surgery. This study describes a multilayered membrane reconstruction strategy for treating high-flow intraoperative CSF leaks during expanded endoscopic endonasal tumor resection (EEA) and presents the associated outcomes, supplemented by surgical video documentation.
Methods:
A retrospective review was performed on patients who underwent multilayered membrane reconstruction for high-flow CSF leaks during EEA.
Results:
From January 2019 to June 2023, 15 patients undergoing EEA experienced high-flow intraoperative CSF leaks and received multilayered membrane reconstruction. Tumor pathologies included pituitary adenoma, craniopharyngioma, and meningioma. After a median postoperative follow-up of 13 months, no postoperative CSF leakage, intracranial infection, meningitis, and pneumocephalus was detected.
Conclusion:
Our preliminary experience indicates that the multilayered membrane reconstruction technique may be a reliable method for achieving a watertight closure of high-flow intraoperative CSF leaks during EEA and warrants further study.
