Effects of high-intensity interval training on lipid metabolism, tumor necrosis factor-α, and C-reactive proteinin overweight children
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Updated: Jun 5, 2025
A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
Xinghao Wang1, Min Fan1, Qiao Meng1
1Department of Sport, Gdansk University of Physical Education and Sport 80-336 Gdansk, Poland.
Insights
High-intensity interval training effectively reduced body mass index and improved lipid profiles and inflammatory markers in overweight children. This intervention offers a promising strategy for pediatric weight management and health improvement.
Area of Science:
- Pediatric Endocrinology
- Sports Medicine
- Exercise Physiology
Background:
- Childhood obesity is a growing public health concern with significant long-term health implications.
- Obesity in children is associated with dyslipidemia and chronic low-grade inflammation, increasing the risk of cardiovascular disease.
- Effective weight management strategies are crucial for improving the health outcomes of overweight children.
Purpose of the Study:
- To evaluate the impact of high-intensity interval training (HIIT) on lipid metabolism and inflammatory markers in overweight children.
- To provide evidence-based clinical guidance for managing weight in pediatric populations.
- To assess the efficacy of HIIT as an intervention for improving health indicators in overweight youth.
Main Methods:
- A retrospective study involving 60 overweight children.
- Participants were randomized into an experimental group (HIIT) and a control group (health education).
- Analysis included baseline and post-intervention physical and biochemical indicators.
Main Results:
- The experimental group demonstrated a significantly greater reduction in Body Mass Index (BMI), with notable changes in male (0.43%) and female (0.85%) participants.
- Significant improvements were observed in triglycerides, total cholesterol, and lipoprotein levels in the HIIT group compared to the control group (P<0.05).
- HIIT intervention led to a significant decrease in serum tumor necrosis factor alpha (from 83.24 ng/L to 64.37 ng/L, P<0.01) and improved C-reactive protein levels (P<0.05).
Conclusions:
- High-intensity interval training is an effective method for enhancing the physical fitness of overweight children.
- HIIT significantly regulates inflammatory factors, contributing to improved metabolic health.
- This training modality supports effective weight loss and offers a viable strategy for pediatric weight management.
Objective:
To investigate the effects of high-intensity interval training on lipid metabolism and inflammatory factors in overweight children, and provide clinical guidance and recommendations for children's weight management.
Methods:
A retrospective study was conducted to analyze 60 overweight children, who were randomly divided into an experimental group (high-intensity interval training) and a control group (health education as intervention). Baseline data, physical indicators, and biochemical indicators were analyzed.
Results:
The body mass Index (BMI) of the experimental group decreased significantly more, with BMI of male and female participants showing change rates of 0.43% and 0.85%, respectively. After intervention, there were significant differences in triglycerides, total cholesterol, and lipoprotein levels between the two groups (P<0.05). After intervention, the serum tumor necrosis factor alpha levels of the experimental group showed significant differences (P<0.01), with an average value decreasing from 83.24 ng/L to 64.37 ng/L, and their C-reactive protein values also showed good intergroup and intragroup statistical differences (P<0.05).
Conclusion:
High-intensity interval training can effectively improve the physical fitness of overweight children, regulate their inflammatory factors, and help with weight loss.
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