Related Experiment Video
Updated: Jun 5, 2025
Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography
Published on: November 24, 2016
Evaluation of the Relationship between QT Dispersion in ECG and Response to Primary PCI in Patients with Acute
Mir Mohammad Sadra Ghods Hosseini1, Samira Dodangeh2, Hamid Reza Javadi2
1Clinical Research Development Unit, Qods Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Insights
QTd intervals significantly decreased after primary angioplasty in ST-elevation myocardial infarction (STEMI) patients. This reduction suggests QTd can serve as a noninvasive indicator of treatment response in STEMI management.
Area of Science:
- Cardiology
- Medical Diagnostics
Background:
- ST-elevation myocardial infarction (STEMI) is a critical condition caused by blocked coronary arteries, leading to heart muscle damage.
- Assessing treatment effectiveness in STEMI is crucial for patient outcomes.
Purpose of the Study:
- To compare QTc and QTd intervals in STEMI patients before and after treatment.
- To evaluate QTd as a potential noninvasive marker for treatment response in STEMI.
Main Methods:
- An analytical cross-sectional study involving 107 STEMI patients undergoing primary PCI.
- Collected data included demographic information, medical history, and QTc/QTd intervals pre- and post-treatment.
- Analyzed the relationship between changes in QT/QTd intervals and ST resolution as a measure of treatment response.
Main Results:
- No significant differences in age, height, weight, or BMI between treatment response groups.
- Mean QTd 1 was higher in the treatment response group, but not statistically significant (P=0.337).
- Mean QTd 2 was significantly lower in the treatment response group (P=0.002).
Conclusions:
- QTd intervals showed a significant reduction after primary angioplasty in STEMI patients.
- QTd can be considered a noninvasive measure to assess treatment response in STEMI.
Background:
St-elevation myocardial infarction (STEMI) is a serious condition that occurs when the blood flow to one or more coronary arteries is blocked, leading to damage or death of the heart muscle (myocardial injury or necrosis). The present study aimed to compare QTc and QTd intervals in patients with STEMI before and 90 minutes after treatment in Booali Sina Hospital, Qazvin, Iran.
Methods:
The present study is an analytical cross-sectional study. Between March 2021 and 2022, 107 patients administered to Booali Sina Hospital, Qazvin, Iran, due to STEMI who underwent primary PCI were enrolled in the study. Data including age, sex, height and weight, disease history, QTc interval before and 90 minutes after treatment, QTd before and 90 minutes after treatment and Ejection fraction values were extracted from the patient's files. Then, the relationship between change in QT and QTd after treatment with response to treatment based on ST Resolution was evaluated. SPSS 20.0 statistical program was used for the statistical analysis. All values are given as mean± standard deviation (SD). A p-value of less than 0.05 was considered as significant.
Results:
The observed mean difference in investigated variables of patients, including age, height, weight, and BMI, was not statistically significant between the two groups (response to treatment and non-response to treatment (P > 0.05). Findings demonstrated that the mean QTd 1 in the response to the treatment group was higher compared to the non-response to the treatment group, and this difference was not statistically significant (P = 0.337). It is remarkable that the mean QTd 2 in the response to treatment group was statistically significantly lower than the non-response to treatment group (P = 0.002).
Conclusion:
We showed that QTd in the studied patients after primary angioplasty reduced significantly compared to the QTd before the treatment, so the QTd can be considered as a noninvasive measure of the response to the treatment in patients with STEMI.
Related Concept Videos
01:29Electrocardiogram
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
01:24ECG Interpretation of Rhythms
Components of the Electrocardiogram
The primary components of a normal ECG waveform in Normal sinus rhythm(NSR) include the P wave, PR interval, QRS complex, ST segment, T wave, and occasionally a U wave.
ECG waveforms are divided by vertical and horizontal lines at standard intervals.
The horizontal axis measures time and rate, and the vertical axis measures amplitude or voltage....
01:25Correlation between ECG and Cardiac Cycle
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
01:30Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
01:28Electrocardiogram Fundamentals
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
01:17Imaging Studies for Cardiovascular System I:Echocardiography
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...