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Updated: Jun 5, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Farnesoid X receptor (FXR) as a potential therapeutic target for lung diseases: a narrative review

Yangyang Cao1, Yuwen Xu1, Jiaqi Zhou1

  • 1Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, China.

Journal of Thoracic Disease
|December 16, 2024
PubMed
Abstract

Insights

Farnesoid X receptor (FXR) plays a role in lung diseases, including non-small cell lung cancer. Understanding FXR's mechanisms offers new therapeutic targets for lung disease treatment.

Area of Science:

  • Molecular Biology
  • Immunology
  • Pulmonology

Background:

  • Farnesoid X receptor (FXR), encoded by the NR1H4 gene, is a nuclear receptor involved in bile acid and lipid metabolism.
  • FXR regulates inflammatory responses and is increasingly recognized for its role beyond classical liver and intestinal targets.

Purpose of the Study:

  • To review the multifaceted roles of FXR in the pathogenesis of various lung diseases.
  • To identify potential diagnostic biomarkers and therapeutic targets for lung conditions linked to FXR.

Main Methods:

  • Comprehensive literature search of PubMed and NCBI databases.
  • Inclusion of studies published between 2000 and 2024.

Main Results:

  • FXR expression is confirmed in lung tissue, indicating its involvement in pulmonary pathophysiology.
  • FXR contributes to lung disease development through diverse mechanisms.
  • FXR promotes non-small cell lung cancer (NSCLC) by upregulating PD-L1, suppressing anti-tumor immunity.

Conclusions:

  • FXR is implicated in the pathogenesis of multiple lung diseases.
  • Further understanding of FXR's roles and mechanisms in lung diseases can inform novel treatment strategies.
Keywords:
Farnesoid X receptor (FXR)acute lung injury (ALI)lung cancerlung fibrosislung ischemia-reperfusion

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