JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

Assessment of tumor biomarkers for prognosis in interstitial lung disease associated with connective tissue disease: a prospective study

  • 0Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Journal of Thoracic Disease +

|

December 16, 2024

|

December 16, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Elevated carcinoembryonic antigen (CEA) levels are linked to progressive pulmonary fibrosis (PPF) in connective tissue disease-associated interstitial lung disease (CTD-ILD). Higher CEA also predicts poorer prognosis and acute exacerbations in CTD-ILD patients.

Area Of Science

  • Pulmonology
  • Rheumatology
  • Oncology

Background

  • Connective tissue disease-associated interstitial lung disease (CTD-ILD) presents uncertainties regarding baseline tumor markers and clinical outcomes.
  • Identifying predictors for progressive pulmonary fibrosis (PPF) and prognosis in CTD-ILD is crucial for patient management.

Purpose Of The Study

  • To investigate the association between baseline serum tumor markers and the development of PPF in CTD-ILD patients.
  • To evaluate the prognostic value of these tumor markers, including their association with mortality and acute exacerbations.

Main Methods

  • A prospective cohort study involving 224 CTD-ILD patients and 63 healthy controls (HCs).
  • Serum levels of nine tumor markers, including CEA and CA125, were measured at baseline.
  • Logistic regression and ROC curve analysis were used to assess marker performance in identifying PPF, with correlation and survival analyses for prognosis.

Main Results

  • Serum CEA and CA125 levels were significantly higher in CTD-ILD patients with PPF compared to those without PPF and HCs.
  • Elevated CEA was identified as the strongest predictor for PPF (AUC=0.64) and remained a significant independent risk factor for PPF, all-cause mortality, and acute exacerbations in multivariate analysis.
  • Higher CEA levels were associated with a 3.42-fold increased risk of PPF.

Conclusions

  • Circulating carcinoembryonic antigen (CEA) is associated with pulmonary fibrosis progression in CTD-ILD.
  • Elevated CEA levels serve as a significant independent risk factor for adverse clinical outcomes, including PPF, mortality, and acute exacerbations in CTD-ILD.

Keywords: