Exploring Bioactive Potential of Streptomyces thinghirensis WAE1 from Wadi El-Natron, Egypt

This study aimed to investigate the bioactive metabolites produced by Streptomyces thinghirensis WAE1, an actinomycete isolated from El-Hamara Lake in Egypt. The discovery of new bioactive compounds from natural sources is crucial for the advancement of therapeutic treatments, and this study aimed to contribute to this field by exploring the potential of Streptomyces thinghirensis WAE1 as a source of such compounds. Streptomyces thinghirensis WAE1 was screened for its ability to produce antimicrobial, antioxidant, and anti-inflammatory metabolites. The results revealed that S. thinghirensis WAE1 exhibited strong antimicrobial activity against Streptococcus pneumoniae and moderate activity against Listeria monocytogenes, Staphylococcus aureus, and Candida albicans. Streptomyces thinghirensis WAE1 also displayed antioxidant activity through scavenging free radicals and chelating iron, and moderate anti-inflammatory activity as determined by its IC₅₀ value. The isolate's demonstration of L-asparaginase activity suggests that S. thinghirensis WAE1 is a promising source of bioactive compounds with potential therapeutic uses. The high salinity and alkalinity of El-Hamara Lake, which create favorable conditions for the production of bioactive metabolites, further add to its potential as a source of actinomycetes strains with bioactive properties. These findings make both S. thinghirensis WAE1 and El-Hamara Lake valuable subjects for further exploration in the field of bioactive compounds.