Networks through the lens of high-frequency oscillations

To date, there is no neurophysiologic or neuroimaging biomarker that can accurately delineate the epileptogenic network. High-frequency oscillations (HFO) have been proposed as biomarkers for epileptogenesis and the epileptogenic network. The pathological HFO have been associated with areas of seizure onset and epileptogenic tissue. Several studies have demonstrated that the resection of areas with high rates of pathological HFO is associated with favorable postoperative outcomes. Recent studies have demonstrated the spatiotemporal organization of HFO into networks and their potential role in defining epileptogenic networks. Our review will present the existing literature on HFO-associated networks, specifically focusing on their role in defining epileptogenic networks and their potential significance in surgical planning.