New Graphs at the braingraph.org Website for Studying the Aging Brain Circuitry

Area of Science:

• Neuroscience
• Medical Imaging
• Computational Biology

Background:

• Human brain connectomes are crucial for understanding brain structure and function.
• Previous research has generated thousands of connectomes from young, healthy subjects.
• The braingraph.org site serves as a repository for these valuable datasets.

Purpose of the Study:

• To introduce a new dataset of human connectomes from the OASIS-3 dataset.
• To include brain connectomes from a wide age range (42-95 years) encompassing healthy and demented individuals.
• To expand the braingraph.org resource for studying brain aging and neurodegenerative diseases.

Main Methods:

• Utilized structural (diffusion) MRI data from the OASIS-3 dataset.
• Processed diffusion MRI data using the Connectome Mapper Toolkit v.3.1.
• Generated and deposited human brain connectomes for analysis.

Main Results:

• A new collection of brain connectomes from healthy and demented subjects is now available on braingraph.org.
• The dataset covers a broad age spectrum, facilitating studies on aging-related brain changes.
• The data includes individuals with varying stages of Alzheimer's disease.

Conclusions:

• The new braingraph.org addition provides a valuable resource for neuroscience research.
• This dataset will aid in understanding the aging brain circuitry in both healthy and diseased states.
• Researchers can leverage this data to investigate the neural underpinnings of cognitive decline and Alzheimer's disease.