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MiRNAs function in the development of resistance against doxorubicin in cancer cells: targeting ABC transporters

Xin-Yan Lu1, Hongxu Jin2

  • 1Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China.

Frontiers in Pharmacology
|December 16, 2024
PubMed

Insights

MicroRNAs (miRNAs) play a key role in doxorubicin resistance by affecting ATP-binding cassette (ABC) transporters. Understanding miRNA-ABC transporter interactions can help overcome chemotherapy resistance in various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Chemotherapy resistance, particularly to doxorubicin, is a major obstacle in cancer treatment.
  • Doxorubicin is a vital chemotherapeutic agent used for breast cancer, leukemia, osteosarcoma, and gastrointestinal cancers.
  • ATP-binding cassette (ABC) transporters are implicated in multidrug resistance.

Purpose of the Study:

  • To review the critical role of microRNAs (miRNAs) in the development of doxorubicin resistance.
  • To elucidate the interaction between miRNAs and ABC transporters in mediating chemotherapy resistance.
  • To identify gaps in knowledge regarding miRNA regulation of ABC transporter expression and activity.

Main Methods:

  • Systematic review of current literature on miRNAs and doxorubicin resistance.
  • Analysis of studies focusing on the interplay between miRNAs and ABC transporters.
  • Assessment of potential therapeutic strategies involving miRNA modulation.

Main Results:

  • miRNAs significantly influence doxorubicin resistance through modulation of ABC transporter expression and activity.
  • A knowledge gap exists in comprehensively understanding how specific miRNAs regulate ABC transporters in cancer cells.
  • Current research highlights the potential of targeting miRNA-ABC transporter interactions to overcome drug resistance.

Conclusions:

  • miRNA research is crucial for understanding and overcoming doxorubicin resistance.
  • Targeting miRNA-ABC transporter pathways offers promising therapeutic strategies.
  • Integrating miRNA modulation into cancer treatment can enhance doxorubicin efficacy.
Keywords:
ABC transporterchemoresisitancedoxorubicinmiRNA - microRNAncRNA

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