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Doppler Optical Coherence Tomography of Retinal Circulation
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Absolute depth-resolved optic axis measurement with catheter-based polarization sensitive optical coherence

Shadi Masoumi1,2, Jaeyul Lee3,4, Georgia L Jones3,5,6

  • 1CERVO Brain Research Center, Université Laval, Québec, Québec, Canada.

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|December 16, 2024
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Summary
This summary is machine-generated.

This study introduces a novel method for accurately measuring tissue optic axis orientation using catheter-based polarization-sensitive optical coherence tomography (PS-OCT). The technique utilizes the catheter sheath as a reference, significantly improving reconstruction accuracy for in-vivo imaging applications.

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Ophthalmology

Background:

  • Polarization-sensitive optical coherence tomography (PS-OCT) provides valuable depth-resolved tissue structural and organizational information.
  • Catheter-based PS-OCT faces challenges in accurately reconstructing optic axis orientation due to probe rotation and system polarization effects.

Purpose of the Study:

  • To develop a robust method for reconstructing absolute depth-resolved optic axis orientation in catheter-based PS-OCT.
  • To overcome limitations in current PS-OCT techniques for in-vivo tissue analysis.

Main Methods:

  • A new reconstruction method employing the intrinsic retardance of the catheter sheath as a stable guide star signal.
  • Rigorous inspection of sheath retardance and optic axis orientation.
  • Validation using a birefringent phantom with known optic axis orientation.

Main Results:

  • The novel method achieved an average absolute deviation (AAD) of 3.28° in optic axis orientation reconstruction, a nearly three-fold improvement over previous methods (9.41° AAD).
  • Accurate reconstruction was maintained even under significant bending stress on the catheter.
  • Successful demonstration of the method in stereotactic catheter-based PS-OCT imaging of a fresh sheep brain.

Conclusions:

  • The developed method enables reliable and robust reconstruction of optic axis orientation in catheter-based PS-OCT.
  • This advancement enhances the diagnostic and mechanistic value of PS-OCT for in-vivo tissue characterization.
  • The technique holds promise for improved clinical applications requiring precise subsurface tissue analysis.