Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

37
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

11.4K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.4K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

899
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
899
Humoral Immune Responses01:36

Humoral Immune Responses

71.4K
Overview
71.4K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

66.9K
Overview
66.9K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

23
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
23

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The metabolic basis of regulated cell death.

Cell metabolism·2026
Same author

Rethinking neonatal <i>Escherichia coli</i> sepsis: the overlooked role of maternally transferred immunity.

Frontiers in immunology·2026
Same author

Efficient preservation of old methane-derived organic carbon in deep-sea surface sediments.

Nature communications·2026
Same author

RNA methylation in cell death: mechanisms and clinical applications.

Molecular cancer·2026
Same author

Fluorogenic probes for intracellular copper detection and the study of cuproptosis.

Methods in cell biology·2026
Same author

Hyperuricemia aggravates acute pancreatitis through CNR1-mediated inflammatory signaling and gut-pancreas axis dysregulation: a multi-omics and clinical study.

Scientific reports·2026
Same journal

Role of incretins in Alzheimer's disease and their impact on behavioral aspects.

Chinese medical journal·2026
Same journal

Asparagine-linked glycosyltransferase 6 deficiency suppresses tumorigenesis in clear cell renal cell carcinoma by regulating apoptosis and immunotherapy sensitivity.

Chinese medical journal·2026
Same journal

Impact of joint effect of parental anthropometrics on fetal growth trajectories: A national multicenter cohort study.

Chinese medical journal·2026
Same journal

Novel treatments for Parkinson's disease.

Chinese medical journal·2026
Same journal

Incidence, DALYs, and death rates of chronic kidney disease in China, 1990-2023: Results from the Global Burden of Disease Study 2023.

Chinese medical journal·2026
Same journal

Reclassifying renal cell carcinoma with pathologic lymph node metastasis: An approach to refining prognostic stratification in patients with AJCC III and IV stages.

Chinese medical journal·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2025

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.1K

Immune aging and infectious diseases.

Ruochan Chen1,2,3, Ju Zou1,2,3, Jiawang Chen1,2,3

  • 1Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Chinese Medical Journal
|December 16, 2024
PubMed
Summary
This summary is machine-generated.

Aging weakens the immune system, increasing infection risk and reducing vaccine effectiveness in older adults. This review examines inflammaging and immunosenescence mechanisms and potential anti-aging strategies.

More Related Videos

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

6.9K
Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans
06:18

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Published on: April 13, 2018

5.9K

Related Experiment Videos

Last Updated: Jun 5, 2025

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.1K
Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

6.9K
Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans
06:18

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Published on: April 13, 2018

5.9K

Area of Science:

  • Gerontology
  • Immunology
  • Infectious Diseases

Background:

  • Global life expectancy increase leads to a larger aging population.
  • Aging impairs innate and adaptive immunity, causing inflammaging and immunosenescence.
  • Cellular senescence and comorbidities exacerbate immune dysfunction in older adults.

Purpose of the Study:

  • To explore molecular and cellular mechanisms of inflammaging and immunosenescence.
  • To understand how aging-associated immune alterations affect infection responses.
  • To evaluate emerging anti-aging strategies for improved health outcomes.

Main Methods:

  • Review of molecular and cellular mechanisms.
  • Focus on genomic instability, telomere attrition, and mitochondrial dysfunction.
  • Discussion of aging-associated immune alterations and infection responses.

Main Results:

  • Aging leads to chronic inflammation (inflammaging) and immune decline (immunosenescence).
  • These changes increase susceptibility to infections and reduce vaccine efficacy.
  • Comorbidities and medications further complicate immune responses in the elderly.

Conclusions:

  • Understanding inflammaging and immunosenescence is crucial for managing infectious diseases in older adults.
  • Emerging anti-aging strategies show promise for mitigating age-related immune decline.
  • Targeting aging mechanisms can improve health outcomes and combat infections in the aging population.