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Core-Shell Bottlebrush Polymers: Unmatched Delivery of Small Active Compounds Deep Into Tissues
Quoc Thang Phan1, Jean-Michel Rabanel1,2, Dikran Mekhjian1
1Faculty of Pharmacy, Université de Montréal, 2940 Chemin de Polytechnique, Montréal, Québec, H3T 1J4, Canada.
Small (Weinheim an Der Bergstrasse, Germany)
|December 16, 2024
Summary
Bottlebrush (BB) polymers, with their unique structures, show improved drug delivery compared to traditional micelles. These advanced nanocarriers enhance cellular uptake and drug penetration for biomedical applications.
Area of Science:
- Polymer Chemistry
- Nanotechnology
- Biomedical Engineering
Background:
- The efficacy of drug delivery systems is critically dependent on the nanovehicle's chemical structure.
- Bottlebrush (BB) polymers offer tunable architectures (backbone length, grafting density, morphology) for novel drug delivery applications.
Purpose of the Study:
- To develop and evaluate core-shell BB polymers as drug delivery nanocarriers.
- To investigate the impact of BB polymer structure on drug loading, cellular uptake, and penetration.
- To compare BB-based nanocarriers with conventional polymeric micelles (PM).
Main Methods:
- Synthesis of core-shell BB polymers via a "grafting-from" strategy.
- Characterization using Nuclear Magnetic Resonance (NMR), Gel Permeation Chromatography (GPC), and Atomic Force Microscopy (AFM).
- Evaluation of drug loading efficiency and cellular penetration using Rhodamine B and Paclitaxel.
Main Results:
- BB polymers were successfully synthesized and characterized.
- BB-based nanocarriers demonstrated superior cellular uptake in 2D and 3D models compared to PM.
- Polymer morphology significantly influenced biological interactions, drug distribution, and particle penetration.
Conclusions:
- Precisely structured unimolecular BB carriers show significant potential for enhanced drug delivery.
- BB polymers represent a promising platform for diverse biomedical applications requiring efficient drug transport.
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