Mpox in assisted conception: should we be worried about this monkey wrench?

Area of Science:

• Virology
• Reproductive Medicine
• Public Health

Background:

• Mpox virus (MPXV) outbreaks have led to a global health emergency declaration by the WHO.
• MPXV has been detected in the semen of infected individuals, presenting a potential occupational hazard.
• Healthcare professionals in medically assisted reproduction (MAR) clinics are at risk due to handling infectious samples.

Purpose of the Study:

• To provide essential information regarding MPXV.
• To highlight critical vigilance and safety measures for MAR professionals.
• To address the risks associated with processing reproductive materials from MPXV-infected persons.

Main Methods:

• This is a commentary, not an experimental study.
• Information synthesis on MPXV transmission and detection in reproductive samples.
• Review of current public health recommendations and expert insights.

Main Results:

• MPXV presence in semen is confirmed, necessitating heightened awareness.
• Clinical embryologists and andrologists face direct exposure risks.
• Standard laboratory protocols may require adaptation to mitigate MPXV transmission.

Conclusions:

• Vigilance in handling semen, oocytes, pre-implantation embryos, and managing pregnancies is crucial.
• MAR clinics must implement specific safety protocols to protect staff and patients.
• Proactive risk assessment and management are essential during MPXV outbreaks.