A new cadinane-type sesquiterpenoid glucoside from Centaurea alexandrina

A new cadinane-type sesquiterpene glucoside, 10α-hydroxy, 1α(H), 6β(H), 7β(H), 8β(H)-cadinane-4-en-8-O-β-D-glucoside (1) as well as, 2 known analogues [sinaicin (2)- linichlorinA (3)], were isolated from the CH₂Cl₂:MeOH organic extract of Centaurea alexandrina. Chemical structures of all isolated compounds were established depending upon the spectroscopic data including, 1D and 2D NMR and HRMS. Colo-205 (colorectal cancer), HepG2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) and cancer cell lines were used to test the cytotoxic potential of the isolated compounds (1-3).