Related Experiment Video
Updated: Jun 5, 2025
10:37
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
95
Kidney consequences of obesity
Edward Nehus1,2, Mark Mitsnefes3
1Department of Pediatrics, West Virginia University School of Medicine Charleston Campus, Charleston, WV, 25314, USA. edward.nehus@camc.org.
Pediatric Nephrology (Berlin, Germany)
|December 16, 2024
Summary
The global obesity epidemic severely impacts kidney health, causing obesity-related kidney disease (ORKD). Understanding its pathophysiology and exploring prevention and treatment are crucial for the nephrology community.
Area of Science:
- Nephrology
- Public Health
- Endocrinology
Background:
- The worldwide obesity epidemic presents a significant public health crisis.
- Kidney health is severely impacted by obesity, leading to obesity-related kidney disease (ORKD).
Purpose of the Study:
- To review the consequences of the obesity epidemic on kidney health.
- To highlight breakthroughs in understanding obesity-related kidney disease (ORKD).
Main Methods:
- Historical review of obesity and ORKD.
- Detailed summary of ORKD pathophysiology.
- Discussion of prevention and treatment strategies.
Main Results:
- ORKD arises from a maladaptive response to caloric surplus.
- Pathways include hemodynamic (hyperfiltration), hormonal (adipokine dysregulation), and lipotoxic mechanisms.
- Mitochondrial oxidative damage is identified as a key cellular injury stage.
Conclusions:
- ORKD is a critical issue for nephrology.
- Future research should focus on early recognition and improved treatment of ORKD.
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