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Related Concept Videos

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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Animal Mitochondrial Genetics02:59

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Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
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Correction to: Genetic Tools in Rodents to Study Cannabinoid Functions.

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Updated: May 5, 2026

Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors
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Genetic Tools in Rodents to Study Cannabinoid Functions.

Krisztina Monory1, Inigo Ruiz de Azua2, Beat Lutz3,4

  • 1Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Current Topics in Behavioral Neurosciences
|December 16, 2024
PubMed
Summary

The endocannabinoid system (ECS) regulates brain functions and is linked to CNS disorders. Genetic engineering tools and rodent models are crucial for understanding ECS roles in health and disease.

Keywords:
Adeno-associated virus (AAV)Cannabinoid receptorsCell-type-specific mutantsEndocannabinoid sensorEndocannabinoid systemMouse modelsTargeted genome editing

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • The endocannabinoid system (ECS) is a key signaling system in mammals, influencing neurotransmission and physiological functions.
  • Dysregulation of the ECS is implicated in various central nervous system (CNS) disorders, including schizophrenia and epilepsy.
  • Understanding the ECS is complex due to intricate expression patterns of its components.

Purpose of the Study:

  • To critically evaluate genetic engineering tools for investigating cannabinoid effects.
  • To comprehensively discuss genetically modified rodent models for studying the ECS.
  • To explore the ECS's role in neuronal and non-neuronal cell populations.

Main Methods:

  • Review of genetic engineering techniques applicable to ECS research.
  • Analysis of existing genetically modified rodent models.
  • Examination of ECS expression in diverse cell types.

Main Results:

  • Genetic engineering provides essential tools for dissecting complex ECS functions.
  • Various genetically modified rodent models offer insights into ECS roles.
  • The ECS is involved in learning, memory, stress, feeding, and aging.

Conclusions:

  • Genetic engineering and specialized rodent models are indispensable for advancing our understanding of the ECS.
  • Further research using these tools will elucidate the ECS's involvement in physiological processes and pathological conditions.