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Lithium Use During Pregnancy in 14 Countries.

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This summary is machine-generated.

Lithium use during pregnancy varied significantly across countries over two decades. Many women stopped lithium during pregnancy and resumed postpartum, highlighting the need for international guidelines for perinatal psychiatric care.

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Area of Science:

  • Perinatal psychiatry
  • Pharmacovigilance
  • Reproductive health

Background:

  • Lithium is crucial for psychiatric relapse prevention but carries teratogenic risks during pregnancy.
  • Information on lithium use patterns in pregnant women is limited.

Purpose of the Study:

  • To investigate the prevalence and patterns of lithium use in pregnant women globally.
  • To analyze temporal trends and variations in lithium prescription during the perinatal period.

Main Methods:

  • A large-scale international cohort study analyzing individual-level pregnancy data from 2000-2021 across 14 countries.
  • Prevalence of lithium use was estimated using prescription data before, during (by trimester), and after pregnancy.

Main Results:

  • Lithium use prevalence varied widely, from 0.07 to 1.56 per 1000 pregnancies across populations.
  • Ten countries showed an increase in lithium use, while one decreased and four remained stable.
  • Lithium use declined during pregnancy trimesters, with postpartum use similar to pre-pregnancy levels, but significant country-specific variations in trimester use were observed.

Conclusions:

  • Significant international disparities exist in lithium use among pregnant women.
  • Discontinuation during pregnancy and reinitiation postpartum is a common pattern, varying by country.
  • Internationally harmonized guidelines are needed for managing psychiatric conditions in pregnant women using lithium.