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Surrogate Clinical End Points in Studies of APOL1-Associated Kidney Disease: Just in Time

Akinlolu O Ojo1

  • 1University of Kansas School of Medicine, Kansas City, Kansas.

Clinical Journal of the American Society of Nephrology : CJASN
|December 16, 2024
PubMed
Abstract

No abstract available in PubMed .

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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