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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Baseline dermoscopic patterns predict long-term changes in nevus diameter and in dermoscopic features.

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Certain nevus dermoscopic patterns, like peripheral globules, indicate increased growth potential in high-risk patients. Most nevi maintain their pattern, but changes often lead to reticular or structureless forms.

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Area of Science:

  • Dermatology
  • Oncology
  • Medical Imaging

Background:

  • Monitoring melanocytic neoplasms is crucial for distinguishing benign nevi from melanoma.
  • Understanding nevus growth dynamics based on dermoscopic patterns aids in early melanoma detection.

Purpose of the Study:

  • To investigate the link between baseline nevus dermoscopic patterns and subsequent diameter changes over long-term monitoring.
  • To assess associations between baseline dermoscopic patterns and changes in nevus dermoscopic pattern and color.

Main Methods:

  • Analysis of 877 nevi from 101 high-risk adult patients with over 14 years between total-body photography (TBP) sessions.
  • Dermoscopic evaluation of nevus patterns and structures at baseline and follow-up, alongside diameter and color assessment from clinical images.

Main Results:

  • Nevi with peripheral globules and negative network patterns showed increased diameter growth.
  • New nevi frequently exhibited peripheral globules and smudgy patterns compared to existing nevi.
  • Dermoscopic pattern changes occurred in 30% of new nevi and 15% of existing nevi, predominantly shifting to reticular or structureless patterns.

Conclusions:

  • Peripheral globules and negative network patterns in nevi predict greater diameter growth in high-risk individuals.
  • The majority of nevi maintain their dermoscopic pattern over time.
  • Observed pattern changes in nevi typically result in reticular or structureless morphologies.