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Updated: Jun 5, 2025

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
Published on: June 29, 2018
Breathing orchestrates synchronization of sleep oscillations in the human hippocampus
Andrew Sheriff1, Guangyu Zhou1, Vivek Sagar1
1Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
Abstract:
Nested sleep oscillations, emerging from asynchronous states in coordinated bursts, are critical for memory consolidation. Whether these bursts emerge intrinsically or from an underlying rhythm is unknown. Here, we show a previously undescribed respiratory-driven oscillation in the human hippocampus that couples with cardinal sleep oscillations. Further, breathing promotes nesting of ripples in slow oscillations, together suggesting that respiration acts as an intrinsic rhythm to coordinate synchronization of sleep oscillations, providing a unique framework to characterize sleep-related respiratory and memory processes.
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