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Updated: Jun 5, 2025
Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics
Published on: November 30, 2012
Wnt-Regulated Therapeutics for Blood-Brain Barrier Modulation and Cancer Therapy
1Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
Abstract:
The Wnt signaling pathway has a significant regulatory part in tissue development and homeostasis. Dysregulation of the Wnt signaling pathway has been associated with many diseases including cancers and various brain diseases, making this signaling pathway a promising therapeutic target for these diseases. In this review, we describe the roles of the Wnt signaling pathway in the blood-brain barrier (BBB) in intracranial tumors and peripheral tumors, from preclinical and clinical perspectives, introduce Wnt-regulated therapeutics including various types of drugs and nanomedicines as BBB modulators for brain-oriented drug delivery and as therapeutic drugs for cancer treatments, and finally discuss limitations and future perspectives for Wnt-regulated therapeutics.
Insights
The Wnt signaling pathway impacts tissue development and is crucial for treating brain diseases and cancers. This review explores Wnt
Area of Science:
- Molecular Biology
- Neuroscience
- Oncology
Background:
- The Wnt signaling pathway regulates tissue development and homeostasis.
- Wnt pathway dysregulation is linked to cancers and brain diseases.
- The Wnt pathway is a potential therapeutic target.
Purpose of the Study:
- To review the Wnt signaling pathway's role in the blood-brain barrier (BBB) for intracranial and peripheral tumors.
- To introduce Wnt-regulated therapeutics for drug delivery and cancer treatment.
- To discuss limitations and future directions for Wnt-based therapies.
Main Methods:
- Literature review of preclinical and clinical studies.
- Analysis of Wnt pathway's role in BBB modulation.
- Examination of Wnt-regulated drugs and nanomedicines.
Main Results:
- Wnt signaling influences the BBB in brain tumors.
- Wnt-regulated therapeutics show potential for drug delivery and cancer therapy.
- Current therapeutic strategies face limitations.
Conclusions:
- The Wnt pathway is a key target for brain tumor therapeutics and drug delivery.
- Further research is needed to overcome limitations and optimize Wnt-based treatments.
- Wnt-regulated nanomedicines offer promising avenues for brain-oriented drug delivery.
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