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Investigating the shared genetic architecture between anxiety and stroke
Yichen Zhang1, Yong'An Jiang1, Hengyi Fan2
1Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, PR China; Nanchang University, Nanchang, Jiangxi 330006, PR China.
Behavioural Brain Research
|December 16, 2024
Summary
Shared genetic factors link anxiety and stroke. This study identified specific genes and a novel SNP, advancing understanding of these conditions.
Area of Science:
- Genetics
- Neuroscience
- Epidemiology
Background:
- Anxiety and stroke share epidemiological links.
- The role of shared genetic factors in anxiety and stroke remains unclear.
- This research investigates the genetic architecture connecting anxiety and stroke.
Purpose of the Study:
- To investigate the shared genetic architecture between anxiety and stroke.
- To identify genetic variants and genes contributing to both conditions.
- To enhance understanding of the pathogenesis of anxiety and stroke.
Main Methods:
- Utilized genome-wide association study (GWAS) summary statistics for anxiety and stroke.
- Performed linkage disequilibrium score regression and genetic covariance analysis.
- Conducted transcriptome-wide association studies (TWAS) and identified risk single nucleotide polymorphisms (SNPs).
Main Results:
- A significant genome-wide genetic correlation was found between anxiety and stroke.
- One novel significant SNP (rs62099231) and one risk locus were identified.
- Three shared risk genes (WDR6, CCDC71, NCKIPSD) for anxiety and stroke were identified.
Conclusions:
- Demonstrated a shared genetic structure between anxiety and stroke.
- Enhanced understanding of the pathogenesis of both conditions.
- Highlighted potential shared therapeutic targets for anxiety and stroke.
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