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Updated: Jun 5, 2025
Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
Published on: December 13, 2017
Nanoparticle biosensors for cardiovascular disease detection
Mohamed J Saadh1, Faris Anad Muhammad2, Rafid Jihad Albadr3
1Faculty of Pharmacy, Middle East University, Amman 11831, Jordan.
Insights
Nanoparticle-based biosensors offer a promising approach for early cardiovascular disease (CVD) detection. These advanced biosensors enable sensitive and specific identification of critical CVD biomarkers, leading to faster interventions.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cardiovascular Diagnostics
Background:
- Early detection of cardiovascular diseases (CVDs) is vital for patient survival and health outcomes.
- Biomarkers like cardiac Troponin-I (cTnI) and NT-proBNP indicate heart muscle injury, such as in acute myocardial infarction (AMI).
- Current diagnostic methods require timely and accurate detection of these biomarkers.
Purpose of the Study:
- To review the application of various nanoparticles in developing sensitive and specific biosensors for CVD biomarker detection.
- To highlight the advantages of nanomaterials in enhancing biosensor performance for early CVD diagnosis.
Main Methods:
- Discussion of optical and electrochemical biosensors utilizing nanoparticles.
- Exploration of how nanomaterials modify sensor surfaces for improved capture molecule immobilization.
- Focus on inorganic nanoparticles for their response intensification, functionalization, biocompatibility, and stability.
Main Results:
- Nanoparticle-modified biosensors demonstrate successful detection of CVD biomarkers.
- Nanomaterials enhance the immobilization of antibodies and aptamers on sensor surfaces.
- Inorganic nanoparticles offer significant advantages in biosensor performance.
Conclusions:
- Nanoparticle-based biosensors are effective tools for the sensitive and specific detection of CVD biomarkers.
- These biosensors facilitate early CVD detection and rapid intervention, potentially reducing morbidity and mortality.
- The use of nanomaterials in biosensor technology represents a significant advancement in cardiovascular diagnostics.
Abstract:
Early detection and management of cardiovascular diseases (CVDs) are crucial for patient survival and long-term health. CVD biomarkers such as cardiac Troponin-I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), creatine kinase MB (CK-MB), Galectin-3 (Gal-3), etc are released into the circulation following heart muscle injury, ie, acute myocardial infarction (AMI). Biosensor technology including the use of nanoparticles can be designed to target specific biomarkers associated with CVD, enabling early detection and more rapid intervention to decrease morbidity and mortality. To date, with the combination of developed nanoparticles, several optical and electrochemical-based biosensors have successfully been used detection of CVD biomarkers. Nanomaterials, when introduced as the modifiers of sensor surfaces like electrodes and gold chips, can result in the more comprehensive and more effective immobilization of capture molecules, ie, antibodies, aptamers and other ligands, due to their large surface area. In recent years, inorganic nanoparticles have regularly been used in the production of biosensors mostly due to their excellent response intensification, adaptable functionalization chemistry, shape control, good biocompatibility, and great stability. In this review, we discuss the application of different kinds of nanoparticles for the sensitive and specific detection of CVD biomarkers.
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