Proteomics of neuropsychiatric disorders

The pathogenesis of neuropsychiatric disorders (NDs) remains largely unclear, hence there is a lack of objective and reliable biomarkers. Proteomics, as a powerful tool for disease biomarkers research, has been largely ignored in the field of NDs. This review summarizes recent research on the application of mass spectrometry-based proteomics in NDs. Proteins associated with NDs have been identified in various sample sources, including blood, urine, saliva, tear, cerebrospinal fluid, and brain tissue. These studies have preliminarily demonstrated the potential of proteomics in NDs and require comprehensive validation in multi-center, large-scale clinical cohorts. We also discuss the challenges and prospects of proteomics in the research of early diagnostic biomarkers for NDs. These findings may provide a foundation for developing proteomic-based diagnostics and advancing precision medicine in NDs.