Related Experiment Video
Updated: Jun 5, 2025

Author Spotlight: Unveiling Mechanisms of Stress Resilience - Significant Findings, Advancements, and Future Research
Published on: December 15, 2023
A two-sample study on the relationship between polygenic risk score of serotonergic polymorphisms and social phobia:
Yuting Yang1, Qi Lan1, Wenting Liang1
1College of Life Science, Northwest University, Xi'an 710069, China.
Backgrounds:
The influence of serotonin function on social phobia has been well-documented, yet the polygenic risk score of serotonergic polymorphisms for social phobia remains unclear.
Methods:
We assessed two aspects of social phobia (i.e., social interaction anxiety and social phobia scrutiny fear) and created a polygenic risk score of seven serotonergic polymorphisms in two independent samples.
Results:
The results from both samples indicated that a greater polygenic risk score, denoting a higher risk of anxiety, was associated with higher levels of social interaction anxiety and social phobia scrutinizing fear. Interestingly, the association between polygenic risk score and social interaction anxiety was mediated by interpersonal adaptability.
Conclusion:
These findings demonstrate the importance of serotonergic polymorphisms in social phobia and unveil a psychological pathway whereby interpersonal adaptability mediates the effect of serotonergic polymorphisms on social phobia.
Related Concept Videos
Social Anxiety Disorder
Theory of Romantic Attachment in Adulthood
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Personality Disorders: Paranoid and Schizoid
Paranoid Personality Disorder
Paranoid personality disorder is...
Personality Theory by Eysenck and Eysenck
In the extroversion/introversion dimension, highly extroverted people are sociable, outgoing, and easily connect with others. In contrast,...
Preparedness and Phobias

