AI models in clinical neonatology: a review of modeling approaches and a consensus proposal for standardized...

Artificial intelligence (AI) is a rapidly advancing area with growing clinical applications in healthcare. The neonatal intensive care unit (NICU) produces large amounts of multidimensional data allowing AI and machine learning (ML) new avenues to improve early diagnosis, enhance monitoring, and provide highly-targeted treatment approaches. In this article, we review recent clinical applications of AI to important neonatal problems, including sepsis, retinopathy of prematurity, bronchopulmonary dysplasia, and others. For each clinical area, we highlight a variety of ML models published in the literature and examine the future role they may play at the bedside. While the development of these models is rapidly expanding, a fundamental understanding of model selection, development, and performance evaluation is crucial for researchers and healthcare providers alike. As AI plays an increasing role in daily practice, understanding the implications of AI design and performance will enable more effective implementation. We provide a comprehensive explanation of the AI development process and recommendations for a standardized performance metric framework. Additionally, we address critical challenges, including model generalizability, ethical considerations, and the need for rigorous performance monitoring to avoid model drift. Finally, we outline future directions, emphasizing the importance of collaborative efforts and equitable access to AI innovations.