Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th...

Area of Science:

• Cardiovascular Science
• Nephrology
• Neurology
• Oncology

Background:

• Augmenting cellular and organ protection is a key goal for treating pathologies like acute myocardial infarction, chronic kidney disease (CKD), and ischemic stroke.
• Despite decades of research, successful clinical translation of organ protection strategies remains elusive.
• The 12th Hatter Cardiovascular Workshop convened experts to discuss challenges and future directions in cardio-, neuro-protection, and interorgan communication.

Purpose of the Study:

• To identify critical research questions and future directions for enhancing organ protection strategies.
• To explore the 'cardio-metabolic-renal' axis in the context of interorgan communication and protection.
• To discuss novel experimental models and therapeutic approaches, including remote ischemic conditioning and cardio-oncology.

Main Methods:

• Discussion and consensus-building among experts at the 12th Hatter Cardiovascular Workshop.
• Review of current understanding and challenges in cellular and organ protection research.
• Identification of key research topics including specific signaling pathways, microvascular roles, and novel therapeutic modalities.

Main Results:

• Key research areas identified include the cardio-metabolic-renal axis, parasympathetic signaling, coronary microvasculature in myocardial infarction, and the RISK pathway.
• The role of extracellular vesicles and the future of clinical studies on remote ischemic conditioning were discussed.
• New experimental models for cardio-oncology investigations were proposed as crucial for future research.

Conclusions:

• Significant progress has been made in understanding organ protection, but clinical translation requires further focused research.
• Interorgan communication, particularly the cardio-metabolic-renal axis, is a vital area for developing comprehensive protection strategies.
• Future research should prioritize novel experimental models, advanced therapeutic interventions like remote ischemic conditioning, and understanding extracellular vesicle function.