Preparation and Characterization of Injectable Augmentation Gels Containing Polycaprolactone and Hyaluronic Acid
Meryem Erken Turkmen1, Mohammadreza Ghaffarlou1, Busra Kilic2
1Bioengineering Division, Institute of Science, Hacettepe University, Ankara, Turkey.
Journal of Cosmetic Dermatology
|December 16, 2024
Summary
This study developed a novel injectable gel using hyaluronic acid (HA) and polycaprolactone (PCL) microspheres for soft tissue augmentation. The PCL/HA gel demonstrated excellent biocompatibility, non-toxicity, and favorable rheological properties for medical applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Dermatology
Background:
- Injectable augmentation gels are crucial for soft tissue treatment.
- Current formulations require continuous improvement to overcome limitations.
Purpose of the Study:
- To develop an innovative injectable gel for soft tissue augmentation.
- To address current trends and specific needs in the field of injectable fillers.
Main Methods:
- A safer hyaluronic acid (HA) gel carrier with a less toxic cross-linker was used.
- Polycaprolactone (PCL) microspheres were prepared via emulsification-solvent evaporation.
- Six different gel formulations combining PCL microspheres and HA gel were created.
Main Results:
- Microspheres exhibited smooth, non-agglomerated surfaces (average size ~45 μm).
- The PCL-HA6 formulation showed favorable rheological properties (G'=553.97 Pa, G''=368.4 Pa, η*=105.9 Pa·s) and injectability.
- In vitro tests indicated high cell viability and increased collagen production for PCL-HA6.
Conclusions:
- The developed PCL/HA gel is biocompatible and non-toxic for soft tissue augmentation.
- The gel shows potential for medical applications due to its favorable rheological characteristics and injectability.
