JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

High Expression of MRPL23 Is Associated with Poor Survival in Clear-Cell Renal Cell Carcinoma

  • 0Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.
Cancers +

|

December 17, 2024

|

December 17, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

MRPL23 protein is lower in clear-cell renal cell carcinoma (ccRCC) but its elevated expression predicts poor patient survival. This finding highlights MRPL23 as a potential prognostic biomarker for ccRCC outcomes.

Area Of Science

  • Oncology
  • Molecular Biology
  • Biomarker Discovery

Background

  • Clear-cell renal cell carcinoma (ccRCC) is a significant health concern.
  • Understanding the molecular mechanisms driving ccRCC progression is crucial for improving patient outcomes.

Purpose Of The Study

  • To investigate the expression patterns of MRPL23 protein and mRNA in ccRCC.
  • To determine the prognostic value of MRPL23 in ccRCC patients.
  • To assess the correlation between MRPL23 expression and clinicopathological features.

Main Methods

  • Immunohistochemistry (IHC) was used to analyze MRPL23 protein expression in 99 ccRCC and 30 adjacent non-tumorous tissues.
  • MRPL23 mRNA levels were analyzed using The Cancer Genome Atlas (TCGA) database.
  • Kaplan-Meier survival analysis and Cox regression were employed to evaluate survival outcomes.

Main Results

  • MRPL23 protein expression was significantly lower in ccRCC tissues compared to normal tissues, while mRNA levels were elevated.
  • MRPL23 expression correlated with several clinicopathological features, including gender, tumor grade, pT status, and disease stage.
  • Elevated MRPL23 protein expression was associated with poorer overall survival (OS) and served as an independent prognostic marker for adverse outcomes in ccRCC patients.

Conclusions

  • MRPL23 protein expression is a potential independent prognostic biomarker for ccRCC.
  • These findings suggest MRPL23's role in ccRCC pathogenesis and its potential as a therapeutic target.

Keywords:

Related Concept Videos

Abnormal Proliferation 02:23

4.4K

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

mTOR Signaling and Cancer Progression 03:03

3.7K

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

The Retinoblastoma Gene 01:20

4.0K

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...