Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

641
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
641
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

99
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
99
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Methods of reducing fever01:22

Methods of reducing fever

642
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
642
Decreased Body Temperature01:29

Decreased Body Temperature

602
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
602
Cancer Therapies02:49

Cancer Therapies

7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BiGART 2025 - the 25th Acta Oncologica Symposium.

Acta oncologica (Stockholm, Sweden)·2025
Same author

Translating Preclinical Studies into the Clinic: Assays and Endpoints Selected to Determine Efficacy.

Molecular cancer therapeutics·2025
Same author

Determining the effects of hyperthermia on the tumor and acute normal tissue response of FLASH radiation.

Acta oncologica (Stockholm, Sweden)·2025
Same author

Late dysphagia after changes in high-dose clinical tumour volume margin for head and neck cancer patients.

Acta oncologica (Stockholm, Sweden)·2025
Same author

Eliminating the high-risk CTV1 margin in DAHANCA oropharyngeal radiotherapy: Dosimetric impact on dysphagia and organ-at-risk doses.

Acta oncologica (Stockholm, Sweden)·2025
Same author

Dual-tracer autoradiographic analysis of glucose metabolism and hypoxia in orthotopic and PDX tumor models.

Acta oncologica (Stockholm, Sweden)·2025

Related Experiment Video

Updated: Jun 5, 2025

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

2.2K

The Rationale for Combining Hypofractionated Radiation and Hyperthermia.

Priyanshu M Sinha1, Charlemagne A Folefac1, Jens Overgaard1

  • 1Experimental Clinical Oncology-Department of Oncology, Aarhus University Hospital, 8200 Aarhus, Denmark.

Cancers
|December 17, 2024
PubMed
Summary

Combining hypofractionated radiation therapy with hyperthermia (heat) shows promise for cancer treatment. This approach targets tumor cells and their microenvironment, but optimal application requires further research.

Keywords:
heathyperthermiahypofractionated radiationpre-clinical and clinical studiesstereotactic radiation

More Related Videos

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
10:23

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

361
Protocol for Long Duration Whole Body Hyperthermia in Mice
07:56

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

11.5K

Related Experiment Videos

Last Updated: Jun 5, 2025

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

2.2K
Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
10:23

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

361
Protocol for Long Duration Whole Body Hyperthermia in Mice
07:56

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

11.5K

Area of Science:

  • Radiation Oncology
  • Cancer Biology
  • Therapeutic Hypothermia

Background:

  • Conventional radiation therapy uses low doses over many fractions.
  • Advanced technology enables hypofractionated irradiation (fewer, high-dose fractions).
  • Hypofractionation may induce vascular damage, worsening tumor hypoxia and acidity.

Purpose of the Study:

  • To review the rationale for combining hypofractionated radiation with hyperthermia.
  • To discuss current research and future directions for this combined therapy.
  • To identify optimal application strategies for maximum therapeutic benefit.

Main Methods:

  • Critical review of pre-clinical and clinical studies.
  • Analysis of the biological mechanisms of hypofractionation and hyperthermia.
  • Discussion of existing data and identification of research gaps.

Main Results:

  • Hypofractionated radiation may induce vascular damage, creating a tumor microenvironment resistant to radiation.
  • Tumor cells in hypoxic and acidic conditions are sensitive to hyperthermia.
  • Preliminary studies suggest potential for combined hypofractionated radiation and hyperthermia.

Conclusions:

  • Combining hypofractionated radiation with hyperthermia is a promising cancer treatment strategy.
  • Further research is needed to determine optimal treatment parameters for clinical efficacy.
  • This combination therapy warrants continued investigation for improved cancer patient outcomes.