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Enhancing Glioblastoma Resection with NIR Fluorescence Imaging: A Systematic Review.

Hadeel M Mansour1, Siddharth Shah2, Tania M Aguilar1

  • 1Department of Neurosurgery, University of Illinois Chicago, Chicago, IL 60612, USA.

Cancers
|December 17, 2024
PubMed
Summary

Near-infrared fluorescence imaging significantly improves glioblastoma (GB) surgery by enhancing tumor visualization and increasing gross total resection rates. This advanced technique leads to better patient outcomes, including improved survival and fewer neurological deficits.

Keywords:
GBMNIRfluorescencefluorescence guided imagingglioblastomanear-infraredneurosurgery

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Area of Science:

  • Neurosurgery
  • Oncology
  • Medical Imaging

Background:

  • Glioblastoma (GB) is a highly aggressive brain tumor with poor prognosis.
  • Current treatments offer limited survival benefits.
  • Accurate tumor margin detection remains a challenge in surgical resection.

Purpose of the Study:

  • To evaluate the impact of near-infrared (NIR) fluorescence imaging on glioblastoma surgery.
  • Assess improvements in tumor visualization, surgical precision, and patient outcomes.

Main Methods:

  • Systematic review of studies on NIR fluorescence in glioblastoma surgery.
  • Inclusion of 135 studies: reviews, clinical trials, RCTs, preclinical studies, and case reports.

Main Results:

  • NIR fluorescence imaging significantly enhances tumor visualization.
  • Gross total resection (GTR) rates increased by 18-22% in clinical studies.
  • Real-time feedback reduces repeat imaging and operational costs.

Conclusions:

  • NIR fluorescence imaging improves surgical precision and extent of resection in glioblastoma.
  • Enhanced GTR correlates with improved progression-free and overall survival.
  • NIR imaging shows potential to become a new standard in intraoperative glioblastoma management.