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Observational Analysis of Point-of-Care Lactate Plus™ Meter in Preclinical Trauma Models
Catharina Gaeth1, Jamila Duarte1, Alvaro Rodriguez1
1Combat Wound Care, United States Army Institute of Surgical Research, 3698 Chambers Pass, JBSA Fort Sam Houston, Houston, TX 78234, USA.
Diagnostics (Basel, Switzerland)
|December 17, 2024
Summary
Two point-of-care devices, Abbott i-STAT® and Nova Biomedical Lactate Plus™, reliably measure blood lactate in trauma. Both devices show similar performance, supporting their use in prehospital settings for trauma patients.
Area of Science:
- Biomedical Engineering
- Clinical Diagnostics
- Emergency Medicine
Background:
- Blood lactate concentration is a key indicator of systemic hypoperfusion, tissue hypoxia, and sepsis in trauma patients.
- It also serves as a prognostic indicator and a marker for treatment response.
- Point-of-care (POC) devices offer rapid lactate measurements from a small blood sample.
Purpose of the Study:
- To compare the lactate values obtained from whole blood using two specific POC devices: Abbott i-STAT® and Nova Biomedical Lactate Plus™.
- To evaluate the agreement between these two devices in measuring lactate levels.
Main Methods:
- An observational analysis of 760 blood samples from four preclinical trauma animal models.
- Simultaneous lactate measurement using the Abbott i-STAT® and Nova Biomedical Lactate Plus™ POC devices.
- Bland-Altman analysis was employed to assess the agreement between the two devices.
Main Results:
- A high Spearman correlation of 0.9180 was observed between the i-STAT® and the Lactate Plus™ meter.
- Both devices indicated a significant increase in lactate levels post-injury (p < 0.05).
- The i-STAT® demonstrated a small bias (-0.0227 ± 0.4542) compared to the Lactate Plus™ meter, with higher readings from the i-STAT® at lactate levels above 2.5 mmol/L.
Conclusions:
- Both the Abbott i-STAT® and Nova Biomedical Lactate Plus™ devices demonstrate comparable performance in measuring lactate levels in trauma scenarios.
- The Nova Biomedical Lactate Plus™ meter provides rapid results using a minimal blood volume.
- The study supports the use of these POC devices for prehospital lactate assessment in trauma care.
