Related Experiment Video

Updated: Jun 4, 2025

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

2.8K

Perspectives on Microbiome Therapeutics in Infectious Diseases: A Comprehensive Approach Beyond Immunology and

Hoonhee Seo1, Sukyung Kim1, Samuel Beck2

  • 1Human Microbiome Medical Research Center (HM·MRC), School of Medicine, Soonchunhyang University, 22, Soonchunhyang-ro, Sinchang-myeon, Asan-si 31538, Chungnam-do, Republic of Korea.

Cells
|December 17, 2024
PubMed

Insights

Microbiome therapeutics, like probiotics, offer a new way to fight infectious diseases by working with the body. These approaches complement traditional methods and show promise for reducing disease severity.

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Global life expectancy has risen, yet infectious diseases remain a major cause of death.
  • Antimicrobial resistance and evolving pathogens necessitate novel therapeutic strategies.
  • The COVID-19 pandemic highlighted the need for approaches beyond pathogen-killing.

Purpose of the Study:

  • To explore microbiome therapeutics as next-generation treatments for infectious diseases.
  • To review the role of probiotics and host-microbiome interactions in managing infections.
  • To discuss the potential and challenges of translating microbiome-based interventions into clinical practice.

Main Methods:

  • This narrative review synthesizes existing research on microbiome therapeutics.
  • It focuses on probiotics and their mechanisms in host-microbiome crosstalk.
  • Evidence for probiotics reducing disease severity and informing therapeutic strategies is examined.

Main Results:

  • Probiotics have demonstrated potential in reducing infectious disease severity.
  • Understanding host-microbiome crosstalk provides insights for novel therapeutic development.
  • Microbiome interventions can promote physiological function alongside immune responses.

Conclusions:

  • Microbiome therapeutics, particularly probiotics, represent a promising complementary strategy for infectious diseases.
  • Harnessing host-microbiome interactions offers a novel approach to infectious disease management.
  • Clinical translation of microbiome therapeutics faces practical challenges that require further investigation.
Keywords:
cooperative defense systeminfectious diseasemicrobiome therapeuticsresistance defensetolerance defense

More Related Videos

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

2.0K
Immunometabolic Circuits in Infection for Advancing Host Directed Therapies11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

356

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
111
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.7K
Key Techniques in Microbiology01:29

Key Techniques in Microbiology

Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K