Related Experiment Video
Updated: Jun 25, 2026
07:59
Folding and Characterization of a Bio-responsive Robot from DNA Origami
Published on: December 3, 2015
14.5K
Recent Advances in DNA Origami-Enabled Optical Biosensors for Multi-Scenario Application
Ziao Hao1, Lijun Kong1, Longfei Ruan1
1State Key Laboratory of Analytical Chemistry for Life Science, National Laboratory of Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210023, China.
Nanomaterials (Basel, Switzerland)
|December 17, 2024
Summary
DNA origami technology is advancing rapidly, enabling the creation of novel optical biosensors. This review summarizes strategies for developing these DNA origami biosensors for advanced biomedical applications.
Area of Science:
- Biotechnology
- Nanotechnology
- Biosensing
Background:
- DNA origami offers programmable, addressable, and biocompatible nanomaterial properties.
- Current applications include cell scaffolds, drug delivery, and enzyme assembly.
- Expanding DNA origami applications requires structures for target identification and reporting.
Purpose of the Study:
- To systematically review universal strategies for developing dynamic, responsive DNA origami.
- To cover both de novo design and modification approaches for DNA origami.
- To discuss applications and advantages of DNA origami biosensors.
Main Methods:
- Review of existing literature on DNA origami design and modification.
- Analysis of strategies for imparting dynamic responsiveness to DNA origami structures.
- Compilation of current and potential applications of DNA origami biosensors.
Main Results:
- Identified universal strategies for creating responsive DNA origami.
- Discussed applications in biomedicine, including diagnostics and imaging.
- Highlighted advantages such as single-molecule resolution and high signal-to-noise ratio.
Conclusions:
- DNA origami biosensors represent a promising advancement over traditional analytical techniques.
- Continued research will further transform DNA origami into versatile optical biosensors.
- The potential applications of DNA origami biosensors are vast and largely unexplored.
More Related Videos
Related Concept Videos
03:31Labeling DNA Probes
DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
02:34DNA Microarrays
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
01:29Modern Molecular Taxonomy
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...