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Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Food Functional Factors in Alzheimer's Disease Intervention: Current Research Progress.

Rong-Zu Nie1,2,3, Huo-Min Luo1,2,3, Ya-Ping Liu1,2,3

  • 1College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China.

Nutrients
|December 17, 2024
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Functional food factors like polyphenols and melatonin show promise in delaying Alzheimer's disease (AD) progression and improving cognitive function. Further research into these natural compounds could lead to new prevention and treatment strategies for AD.

Keywords:
Alzheimer’s diseasefood functional factorspolyphenolspolysaccharidesunsaturated fatty acids

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Area of Science:

  • Neuroscience
  • Nutritional Science
  • Gerontology

Background:

  • Alzheimer's disease (AD) poses a growing global health challenge due to population aging.
  • Current AD treatments offer limited efficacy, highlighting the need for novel prevention and intervention strategies.
  • Functional food factors represent a promising area for safe and natural AD management.

Purpose of the Study:

  • To review the potential of functional food factors in preventing and treating Alzheimer's disease.
  • To summarize the neuroprotective mechanisms of various bioactive compounds found in foods.
  • To identify future research directions for developing nutritional interventions for AD.

Main Methods:

  • Literature review of recent studies on functional food factors and Alzheimer's disease.
  • Analysis of research findings on compounds including polyphenols, polysaccharides, unsaturated fatty acids, melatonin, and caffeine.
  • Examination of the effects of these factors on AD pathology and cognitive function.

Main Results:

  • Polyphenols, polysaccharides, unsaturated fatty acids, melatonin, and caffeine demonstrate positive effects in delaying AD.
  • These compounds exhibit antioxidant, anti-inflammatory, neuroprotective, and cognitive-enhancing properties.
  • Specific mechanisms include inhibiting Aβ production, Tau phosphorylation, oxidative stress, and inflammation, while promoting neuronal growth and mitochondrial homeostasis.

Conclusions:

  • Functional food factors offer a promising avenue for AD prevention and treatment.
  • Further investigation into their mechanisms and development into functional foods or supplements is warranted.
  • These natural compounds could provide valuable support for managing Alzheimer's disease.