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Updated: Jun 4, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Stereoselective Total Synthesis of Natural Decanolides Bellidisin C and Pinolidoxin
Jingjing Bi1,2, Minhao Chen3,4, Pengpeng Nie3,4
1School of Pharmacy, Xinyang Agriculture and Forestry University, Xinyang 464000, China.
Abstract:
A divergent total synthesis of bioactive, naturally occurring decanolides, pinolidoxin and bellidisin C, was accomplished by taking advantage of chiral templates L-ribose and L-malic acid. In particular, bellidisin C, which is the first total synthesis so far, was achieved through a cascade reaction of reductive elimination and nucleophilic addition in a one-pot process and a sodium-alkoxide-promoted intramolecular lactonization as the key steps.
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