Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

UV–Vis Spectrometers

UV–Vis Spectrometers

The absorbance of UV and visible (UV–visible) radiations is measured using a UV–visible spectrophotometer. Deuterium lamps, which emit UV radiation, and tungsten lamps, which produce radiation in the visible region, are used as light sources in UV–visible spectrophotometers. A monochromator or prism is used for diffraction grating, i.e., to split the incoming radiation into different wavelengths. A system of slits is used to focus the desired wavelength on the sample cell.

Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview

Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview

Ultraviolet–visible (UV–visible or UV–Vis) spectroscopy is an analytical technique that investigates the interaction between matter and UV–Vis light within the electromagnetic spectrum. This method is widely used for its versatility, simplicity, and relatively quick data acquisition, making it valuable for both qualitative and quantitative analysis. When UV–Vis radiation passes through a material, molecules absorb light depending on the energy required for...

Super-resolution Fluorescence Microscopy

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...

IR Spectrometers

IR Spectrometers

There are two main infrared (IR) spectrophotometers: dispersive IR spectrometers and Fourier transform infrared (FTIR) spectrometers. In a dispersive IR spectrometer, a beam of infrared radiation produced by a hot wire is divided into two parallel equal-intensity beams using mirrors. One beam passes through the sample, while another is a reference beam. The beams then move through the monochromator, which separates the radiations into a continuous spectrum of different frequencies. The...

High-Resolution Mass Spectrometry (HRMS)

High-Resolution Mass Spectrometry (HRMS)

The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the sum of the masses of protons and neutrons inside, considering the masses of protons and neutrons as equal. However, the masses of the proton (1.6726 × 10−24 g) and neutron (1.6749 × 10−24 g) are not truly equal. There is a minor error in the expression of atomic masses relative to the simplest atom of hydrogen. For...

Raman Spectroscopy Instrumentation: Overview

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Large-scale integrated optoelectronic chaos for machine learning acceleration.

Nature communications·2026

Same author

Photonic computing enabled end-to-end image compression and reconstruction with adjustable ratio and high-fidelity.

Nature communications·2026

Same author

Metasurface spectrometers beyond resolution-sensitivity constraints.

Science advances·2024

Same author

Ideal Photothermal Materials Based on Ge Subwavelength Structure.

Molecules (Basel, Switzerland)·2024

Same author

Advances in cost-effective integrated spectrometers.

Light, science & applications·2022

Same author

Hybrid Fourier-domain mode-locked laser for ultra-wideband linearly chirped microwave waveform generation.

Nature communications·2020

Same journal

Correction: Chen et al. Chemical Composition of <i>Litsea pungens</i> Essential Oil and Its Potential Antioxidant and Antimicrobial Activities. <i>Molecules</i> 2023, <i>28</i>, 6835.

Molecules (Basel, Switzerland)·2026

Same journal

Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754.

Molecules (Basel, Switzerland)·2026

Same journal

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026

Same journal

Correction: Zueva et al. Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry. <i>Molecules</i> 2020, <i>25</i>, 1371.

Molecules (Basel, Switzerland)·2026

Same journal

1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications.

Molecules (Basel, Switzerland)·2026

Same journal

Comparative Phytochemical Studies on the Aerial Parts of <i>Teucrium davaeanum</i> Coss. and <i>Teucrium zanonii</i> Pamp.

Molecules (Basel, Switzerland)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 4, 2025

High Resolution Phonon-assisted Quasi-resonance Fluorescence Spectroscopy

High Resolution Phonon-assisted Quasi-resonance Fluorescence Spectroscopy

Published on: June 28, 2016

High-Sensitivity, High-Resolution Miniaturized Spectrometers for Ultraviolet to Near-Infrared Using Guided-Mode

Jingjun Wu¹, Cong Wei¹, Hanxiao Cui²

¹School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.

Molecules (Basel, Switzerland)

|December 17, 2024

Summary

This summary is machine-generated.

This study introduces a novel guided-mode resonance filter (GMRF) spectrometer that significantly enhances sensitivity and spectral resolution for on-site chemical analysis. The GMRF approach improves detection limits for trace analytes in complex samples.

Keywords:

guided-mode resonance high resolution high sensitivity miniaturized spectrometers spectral analysis

More Related Videos

Excitation-Scanning Hyperspectral Imaging Microscopy to Efficiently Discriminate Fluorescence Signals

Excitation-Scanning Hyperspectral Imaging Microscopy to Efficiently Discriminate Fluorescence Signals

Published on: August 22, 2019

Author Spotlight: Unveiling the Potential of VSFG Microscopy in Studying Mesoscopically Heterogeneous Self-Assembled Structures

Author Spotlight: Unveiling the Potential of VSFG Microscopy in Studying Mesoscopically Heterogeneous Self-Assembled Structures

Published on: December 1, 2023

Related Experiment Videos

Last Updated: Jun 4, 2025

High Resolution Phonon-assisted Quasi-resonance Fluorescence Spectroscopy

High Resolution Phonon-assisted Quasi-resonance Fluorescence Spectroscopy

Published on: June 28, 2016

Excitation-Scanning Hyperspectral Imaging Microscopy to Efficiently Discriminate Fluorescence Signals

Excitation-Scanning Hyperspectral Imaging Microscopy to Efficiently Discriminate Fluorescence Signals

Published on: August 22, 2019

Author Spotlight: Unveiling the Potential of VSFG Microscopy in Studying Mesoscopically Heterogeneous Self-Assembled Structures

Author Spotlight: Unveiling the Potential of VSFG Microscopy in Studying Mesoscopically Heterogeneous Self-Assembled Structures

Published on: December 1, 2023

Area of Science:

Analytical Chemistry
Optical Engineering
Spectroscopy

Background:

Miniaturized spectrometers enable real-time on-site spectral analysis for environmental, healthcare, and industrial applications.
Challenges in compact spectrometers include achieving high sensitivity and spectral resolution for detecting low-concentration analytes or subtle spectral variations.

Purpose of the Study:

To introduce an innovative spectrometer design utilizing guided-mode resonance filters (GMRFs) to overcome limitations in sensitivity and resolution.
To demonstrate the enhanced performance of GMRF-based spectrometers for chemical and biological analysis.

Main Methods:

Employed guided-mode resonance filters (GMRFs) functioning as narrow band-stop filters to selectively block specific spectral bands.
Integrated GMRFs with complementary metal oxide semiconductor (CMOS) technology for scalable production.
Evaluated spectrometer performance using fluorescence spectroscopy of mouse jejunum.

Main Results:

Achieved a spectral resolution of 0.8 nm over a 370-810 nm range.
Demonstrated over tenfold greater sensitivity compared to conventional grating spectrometers in fluorescence spectroscopy.
Confirmed the effectiveness of GMRFs in enhancing spectral encoding and maximizing light energy extraction.

Conclusions:

The GMRF-based spectrometer offers significantly improved sensitivity and resolution for detecting trace analytes in complex matrices.
This technology holds transformative potential for chemical analysis, materials science, and biomedical research.
Compatibility with CMOS technology facilitates scalable and cost-effective production for broader adoption.