Combating Bacterial Resistance by Polymers and Antibiotic Composites.

Area of Science:

• Materials Science
• Biotechnology
• Medicinal Chemistry

Background:

• Antibiotic resistance is a significant global health challenge.
• Overuse of antibiotics has led to the rise of resistant pathogens.
• Antimicrobial peptides in polymers and nanoparticles offer a novel alternative.

Purpose of the Study:

• To review the synthesis of polymers with antimicrobial properties.
• To evaluate the antimicrobial activity of these novel materials.
• To identify potential alternatives to traditional antibiotics.

Main Methods:

• Literature review of scientific works published in the last 15 years.
• Synthesis of polymers and nanoparticles with antimicrobial properties.
• Extraction and analysis of data on antimicrobial activity.

Main Results:

• Fluorinated surfactants (Quaterfluo® series) showed significant antimicrobial effects.
• Biopolymers like chitosan and starch were effective as iodophors.
• Quaternary phosphonium salts demonstrated enhanced antimicrobial activity and thermal stability compared to ammonium counterparts.

Conclusions:

• Polymeric materials and nanoparticles show potential as future alternatives to antibiotics.
• Further research is required to establish clinical efficacy and safety profiles.
• Functional doses and toxicity assessments are crucial for clinical application.