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Carbon Based Polymeric Nanocomposite Hydrogel Bioink: A Review.

Alle Madhusudhan¹, Tejaskumar A Suhagia¹, Chhavi Sharma²

¹Department of Chemistry, The University of Memphis, Memphis, TN 38152, USA.

|December 17, 2024

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Carbon-based nanocomposite hydrogels (NCHs) integrate nanoparticles like graphene and carbon nanotubes to improve mechanical strength and conductivity. These advanced materials show promise for drug delivery, tissue engineering, and wound healing.

Area of Science:

Biomedical Materials Science
Polymer Chemistry
Nanotechnology

Background:

Hydrogels are versatile polymeric networks with high water content.
Traditional hydrogels often lack the mechanical strength and functionality for advanced biomedical applications.
Integrating nanoparticles into hydrogels offers a route to enhanced material properties.

Purpose of the Study:

To explore the development and applications of carbon-based polymeric nanocomposite hydrogels (NCHs).
To investigate the impact of various carbon nanoparticles on hydrogel properties and performance.
To highlight the potential of NCHs in drug delivery, tissue engineering, and wound healing.

Main Methods:

Incorporation of carbon nanoparticles (graphene, CNTs, CDs, AC) into polymeric hydrogel matrices.

Keywords:

activated charcoal (AC)carbon dots (CDs)carbon nanotubes (CNTs)graphene nanocomposite hydrogels

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Characterization of enhanced mechanical strength, electrical conductivity, and bioactivity.

Evaluation of NCHs in specific biomedical applications like drug delivery, 3D bioprinting, and wound healing.

Main Results:

Graphene and CNTs significantly improve mechanical and electrical properties, enabling advanced tissue scaffolding and bioinks.
Carbon dots (CDs) provide fluorescence for theranostic applications, combining imaging and therapy.
Activated charcoal (AC) enhances biocompatibility and antibacterial properties for wound healing and electroactive scaffolds.

Conclusions:

Carbon-based NCHs offer superior properties compared to conventional hydrogels.
These nanocomposites are highly effective for diverse biomedical applications, including drug delivery, tissue engineering, and wound healing.
Further research is needed to overcome challenges in optimization, biocompatibility, dispersion, and scalability for clinical translation.