Related Experiment Video
Updated: Jun 4, 2025
07:05
Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
Published on: September 22, 2015
10.0K
3D-Printed Poly(ester urethane)/Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/Bioglass Scaffolds for Tissue
Nayla J Lores1, Beatriz Aráoz2, Xavier Hung1
1Research Institute for Materials Science and Technology, INTEMA (UNMdP-CONICET), Av. Colón 10850, Mar del Plata B7606BWV, Argentina.
Polymers
|December 17, 2024
Summary
This study developed novel biodegradable composite filaments for 3D printing bone tissue engineering scaffolds. Blending poly(ester urethanes) with PHBV and Bioglass 45S5® enhanced mechanical properties, showing promise for customized bone regeneration applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Polymer Science
Background:
- Biodegradable polymers and bioceramics are crucial for tissue regeneration scaffolds.
- Bioresorbable segmented poly(ester urethanes) (SPEUs) are printable but lack bioactivity and have low elastic modulus, limiting their use in bone tissue engineering.
- Developing composite filaments from SPEUs presents challenges.
Purpose of the Study:
- To prepare and characterize biodegradable filaments and 3D structures from SPEU-poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) blends and SPEU-PHBV-Bioglass 45S5® (BG) composites.
- To evaluate their potential for bone tissue engineering applications.
Main Methods:
- Processing SPEU-PHBV blends and SPEU-PHBV-BG composites into filaments.
- Fabricating 3D structures using additive manufacturing.
- Comprehensive characterization of morphology, thermal, and mechanical properties.
- Optimizing blend composition, Bioglass content, and processing parameters.
Main Results:
- 3D structures from SPEU-PHBV blends exhibited excellent dimensional precision.
- SPEU-PHBV-BG composites showed some printing defects but promising properties.
- Incorporation of PHBV (70:30 w/w) and 5 wt% BG reinforced the materials, enhancing elastic modulus and compressive behavior.
- The compressive stress of the printed scaffold (1.48 ± 0.13 MPa) is suitable for human proximal tibial trabecular bone.
Conclusions:
- SPEU-PHBV-BG composites demonstrate potential as printable biomaterials for bone tissue engineering.
- Careful control over material composition and processing is key to achieving desired mechanical properties.
- These materials offer a promising route for manufacturing customized scaffolds for bone regeneration.
