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Related Concept Videos

Heart Valves01:16

Heart Valves

14.9K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
14.9K

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Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
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A Novel Polymer Film to Develop Heart Valve Prostheses.

Irina Yu Zhuravleva1, Anna A Dokuchaeva1, Andrey A Vaver1

  • 1E. Meshalkin National Medical Research Center of the RF Ministry of Health, 15 Rechkunovskaya St., Novosibirsk 630055, Russia.

Polymers
|December 17, 2024
PubMed
Summary

REPEREN® polymer film shows potential for artificial heart valves, offering superior mechanical strength and biocompatibility compared to traditional bovine pericardium. Its rough surface enhances hemocompatibility for improved valve performance.

Keywords:
REPEREN® filmbiocompatibilitybiomaterialsheart valve engineeringhemocompatibilitypolymeric heart valves

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Cardiovascular Engineering

Background:

  • Bioprosthetic heart valves face calcific degeneration, limiting their lifespan.
  • Transcatheter valve technology necessitates advanced, durable biomaterials.
  • Polymer chemistry offers alternatives to biological tissues for valve prostheses.

Purpose of the Study:

  • To evaluate the properties of REPEREN® polymer film for potential use in heart valve prostheses.
  • To compare REPEREN® with cross-linked bovine pericardium (DE-BP) in terms of mechanical and biocompatibility aspects.

Main Methods:

  • REPEREN® film characterization using SEM and AFM.
  • Assessment of hydrophilicity, cytocompatibility (EA.hy926 cells), and hemocompatibility (platelet adhesion/aggregation).
  • Mechanical testing and subcutaneous implantation in rats for 90 days, followed by histological analysis.

Main Results:

  • REPEREN® exhibits distinct smooth and rough surfaces; the rough surface demonstrates enhanced hydrophilicity, hemocompatibility, and cytocompatibility.
  • REPEREN® possesses higher ultimate tensile stress than DE-BP.
  • Subcutaneous implantation revealed superior biocompatibility of REPEREN® compared to DE-BP.

Conclusions:

  • REPEREN® polymer film demonstrates promising properties for the development of polymeric heart valves.
  • The material's mechanical strength and biocompatibility suggest it as a viable alternative to current bioprostheses.
  • Further research on valve durability and in vivo performance in large animals is warranted.