Genetic Variants Linked to Opioid Addiction: A Genome-Wide Association Study.
Shailesh Kumar Panday1, Vijay Shankar2, Rachel Ann Lyman2
1Department of Physics and Astronomy, Clemson University, Clemson, SC 29634, USA.
International Journal of Molecular Sciences
|December 17, 2024
Summary
Genetic variants play a role in opioid use disorder (OUD) risk. This study identified new genetic variants and pathways associated with persistent opioid use, offering insights into OUD development and potential therapeutic targets.
Area of Science:
- Genetics
- Pharmacology
- Neuroscience
Background:
- Opioid use disorder (OUD) is a significant global health issue with complex origins.
- While social and environmental factors are known contributors, genetic predispositions are increasingly recognized.
- Understanding genetic variants associated with OUD risk is crucial for prevention and treatment.
Purpose of the Study:
- To investigate genetic variants linked to the risk of developing opioid use disorder (OUD) following opioid exposure.
- To identify novel genetic markers and pathways associated with persistent opioid use.
Main Methods:
- Genome-wide association studies (GWAS) were conducted on 23 subjects (11 controls, 12 cases) who received opioid painkillers.
- Saliva samples underwent DNA sequencing and variant calling.
- Analysis included identifying significant variants, novel variants in cases vs. controls, and co-occurrence analysis within genes.
Main Results:
- Thirteen genome-wide significant variants and two previously reported missense variants (rs6265, rs1799971 in OPRM1) were identified.
- Eleven new variants, exclusive to persistent opioid users, were discovered.
- Eight additional genes, including LRFN3, ZMIZ1, RYR3, and OR1L6, showed multiple variants in cases, implicating them in OUD.
Conclusions:
- Genetic variants significantly contribute to the risk of developing opioid use disorder.
- Identified variants and associated pathways (calcium signaling, circadian entrainment, opioid signaling) provide new insights into OUD pathogenesis.
- These findings may inform the development of targeted interventions for OUD.
Keywords:
case-control genome-wide association studyfunctional enrichment analysisgenetic variantsprotein–protein interaction networkMore Related Videos
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