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The Emerging Role of p21 in Diabetes and Related Metabolic Disorders

Omar Elmitwalli1, Radwan Darwish1, Lana Al-Jabery1

  • 1Department of Medicine, Royal College of Surgeons in Ireland-Medical University of Bahrain Busaiteen, Adliya P.O. Box 15503, Bahrain.

International Journal of Molecular Sciences
|December 17, 2024
PubMed

Insights

The protein p21, a cell cycle regulator, is increasingly linked to metabolic processes and diabetes. Targeting p21 may offer new therapies for metabolic disorders and diabetes.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Endocrinology

Background:

  • The protein p21 is a key regulator of the cell cycle, involved in DNA damage response, apoptosis, senescence, and cell cycle arrest.
  • While known for its role in cell cycle control and cancer, emerging evidence highlights p21's involvement in metabolic processes.

Purpose of the Study:

  • To comprehensively review the scientific literature on the involvement of p21 in metabolic processes, diabetes etiology, pancreatic function, glucose homeostasis, and insulin resistance.
  • To provide an overview of therapies targeting p21 for metabolic disorders.

Main Methods:

  • Literature review and synthesis of existing scientific studies.
  • Analysis of the role of p21 in various metabolic pathways and its connection to diabetes pathogenesis.

Main Results:

  • p21 is implicated in both direct and indirect regulation of metabolic processes.
  • Recent research suggests a significant contribution of p21 to the development of diabetes.
  • p21 influences key aspects of metabolic health, including glucose homeostasis and insulin resistance.

Conclusions:

  • A deeper understanding of the p21-diabetes interrelationship is crucial for developing effective therapeutic strategies.
  • Targeting p21 presents a promising avenue for addressing metabolic disorders and the global diabetes crisis.
Keywords:
diabetesinsulin resistancemetabolismp21therapeutic strategies

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