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Published on: January 27, 2019
Crossing Age Boundaries: The Unifying Potential of Presepsin in Sepsis Diagnosis Across Diverse Age Groups
Edmilson Leal Bastos de Moura1,2, Rinaldo Wellerson Pereira1,3
1Health Sciences Doctoral Program, University of Brasília (UnB), Brasilia 70910-900, Distrito Federal, Brazil.
Insights
Early sepsis diagnosis is crucial. Presepsin shows potential as a reliable biomarker across all age groups, aiding in timely treatment and improving outcomes for sepsis patients.
Area of Science:
- Biochemistry
- Clinical Medicine
- Pathophysiology
Background:
- Sepsis is a life-threatening condition with significant global impact.
- Current sepsis diagnosis relies on clinical signs and scores, with microbiological cultures as the gold standard.
- A single, reliable biomarker for early sepsis detection remains elusive.
Purpose of the Study:
- To review the diagnostic and prognostic performance of presepsin.
- To evaluate presepsin as a biomarker in various age demographics.
Main Methods:
- Narrative review of existing literature.
- Analysis of studies on presepsin's role in sepsis diagnosis and prognosis.
Main Results:
- Presepsin demonstrates potential as a diagnostic biomarker for sepsis.
- Its performance is evaluated across different age groups, from neonates to the elderly.
- Presepsin shows promise in identifying sepsis at all life stages.
Conclusions:
- Presepsin is a promising biomarker for sepsis diagnosis and prognosis.
- Its utility spans all age groups, offering a potential tool for early detection.
- Further research may solidify presepsin's role in clinical sepsis management.
Abstract:
Sepsis is a pervasive condition that affects individuals of all ages, with significant social and economic consequences. The early diagnosis of sepsis is fundamental for establishing appropriate treatment and is based on warning scores and clinical characteristics, with positive microbiological cultures being the gold standard. Research has yet to identify a single biomarker to meet this diagnostic demand. Presepsin is a molecule that has the potential as a biomarker for diagnosing sepsis. In this paper, we present a narrative review of the diagnostic and prognostic performance of presepsin in different age groups. Given its particularities, it is identified that presepsin is a potential biomarker for sepsis at all stages of life.
