Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hemodialysis I: Introduction

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrated immune and endothelial profiling predicts 90-day mortality in postoperative sepsis and septic shock.

EBioMedicine·2026

Same author

The OxyCam: A novel hand-held vital microscope for quantitative measurement of microcirculatory perfusion and oxygenation.

Journal of intensive medicine·2026

Same author

Microcirculatory response and leukocyte activation in patients undergoing elective cardiac surgery with cardiopulmonary bypass.

Journal of intensive medicine·2026

Same author

KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients.

BMJ open·2026

Same author

What every intensivist should know about the endothelial glycocalyx.

Journal of critical care·2026

Same author

Protective Ventilation During Controlled and Partial Ventilatory Support in ARDS: Clinical-Physiological Background and Monitoring.

Journal of clinical medicine·2026

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Endothelial Protection and Improved Micro- and Macrocirculation with Hemoadsorption in Critically Ill Patients.

Marton Papp^1,2, Can Ince³, Jan Bakker^4,5,6,7

¹Department of Anesthesiology and Intensive Therapy, Semmelweis University, 78 Üllői St., 1082 Budapest, Hungary.

Journal of Clinical Medicine

|December 17, 2024

Summary

Extracorporeal hemoadsorption may protect critically ill patients by reducing harmful cytokines and toxic proteins. This approach offers a potential strategy for endothelial protection during hyperinflammation and vasoplegic shock.

Keywords:

capillary leakage cytokines endothelium hemoadsorption sepsis septic shock

More Related Videos

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Published on: September 5, 2017

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

Related Experiment Videos

Last Updated: Jun 12, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Published on: September 5, 2017

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

Area of Science:

Critical Care Medicine
Immunology
Vascular Biology

Background:

Dysregulated immune responses cause excessive cytokine release, leading to vasoplegia, shock, and multiorgan failure.
The endothelium and glycocalyx maintain vascular homeostasis but are damaged during hyperinflammation.
Toxic proteins and cytokines contribute to endothelial and glycocalyx injury in critical illness.

Purpose of the Study:

To review current knowledge on hyperinflammation and endothelial damage in critically ill patients.
To explore the role of extracorporeal hemoadsorption in managing these conditions.
To propose the hypothesis of "endothelial protection with hemoadsorption".

Main Methods:

Literature review of in vitro, animal, and human studies.
Analysis of data on cytokine reduction and toxic protein removal by hemoadsorption.
Synthesis of findings to support a novel therapeutic hypothesis.

Main Results:

Extracorporeal hemoadsorption effectively reduces circulating cytokine levels.
Hemoadsorption may remove toxic proteins implicated in endothelial and glycocalyx damage.
Evidence suggests potential benefits in mitigating hyperinflammatory states.

Conclusions:

Hyperinflammation severely compromises endothelial and glycocalyx integrity.
Extracorporeal hemoadsorption presents a promising modality for reducing inflammatory mediators.
The hypothesis of "endothelial protection with hemoadsorption" warrants further investigation in critically ill patients.