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FACEmemory®, an Innovative Self-Administered Online Memory Assessment Tool
Montserrat Alegret1,2, Josep Blazquez-Folch1, Alba Pérez1
1Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08028 Barcelona, Spain.
Journal of Clinical Medicine
|December 17, 2024
Summary
FACEmemory, an online memory test, shows promise in detecting early cognitive impairment, particularly amnestic MCI. This tool can help address underdiagnosis and promote early intervention strategies for Alzheimer's disease.
Area of Science:
- Neuroscience
- Gerontology
- Psychology
Background:
- Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI) are frequently underdiagnosed.
- Early detection of cognitive deficits is critical for effective intervention.
- FACEmemory is a novel, self-administered online memory test with voice recognition designed for accessible cognitive deficit detection.
Purpose of the Study:
- To examine the neuropsychological correlations between FACEmemory subscores and established cognitive composites.
- To develop an optimized algorithm using FACEmemory data and demographics for differentiating cognitively healthy (CH) individuals from those with MCI.
- To assess the utility of FACEmemory in identifying specific MCI subtypes, including amnestic MCI (aMCI) and non-amnestic MCI (naMCI).
Main Methods:
- 669 participants (266 CH, 206 naMCI, 197 aMCI) were analyzed.
- Multiple linear regression was employed to associate FACEmemory subscores and demographics (age, sex, schooling) with cognitive composites.
- Machine learning models were evaluated to determine the best algorithm for CH vs. MCI discrimination.
Main Results:
- FACEmemory scores demonstrated significant associations with memory (ρ = 0.67), executive functions (ρ = 0.63), visuospatial abilities (ρ = 0.55), language (ρ = 0.43), praxis (ρ = 0.52), and attention (ρ = 0.31).
- An optimized algorithm successfully distinguished CH from aMCI individuals with a FACEmemory cutoff score of 44.5, yielding 81% sensitivity and 72% specificity.
- The study identified specific FACEmemory subscore associations across various cognitive domains.
Conclusions:
- FACEmemory is a valuable online tool for detecting early cognitive impairment, especially aMCI.
- The findings suggest FACEmemory can aid in combating the underdiagnosis of MCI and dementia in community settings.
- This accessible technology supports the promotion of timely preventive strategies for cognitive decline.
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