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Gallbladder function: methods for measuring filling and emptying.

R P Sarva, D P Shreiner, D Van Thiel

    Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
    |February 1, 1985
    PubMed
    Summary
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    A 45-minute infusion of cholecystokinin octapeptide is optimal for gallbladder emptying, achieving higher ejection fractions than rapid injections. This method ensures consistent gallbladder emptying without adverse effects.

    Area of Science:

    • Gastroenterology
    • Nuclear Medicine
    • Pharmacology

    Background:

    • Cholecystokinin (CCK) octapeptide stimulates gallbladder contraction.
    • Understanding optimal CCK octapeptide administration is crucial for diagnostic and therapeutic applications.

    Purpose of the Study:

    • To determine the optimal dose and administration method of CCK octapeptide for gallbladder emptying.
    • To characterize gallbladder filling and emptying kinetics using cholescintigraphy.

    Main Methods:

    • Cholescintigraphy with [99mTc] disofenin in 22 healthy patients.
    • Administered CCK octapeptide via 45-min constant intravenous infusion (20 ng/kg/hr) and 1-min injection (20 ng/kg).
    • Assessed gallbladder filling rates and ejection fractions.

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    Main Results:

    • Gallbladder filling peaked at 30 min, complete by 1 hr.
    • 45-min infusion yielded 77.2% ejection fraction; 1-min injection yielded 52.2% ejection fraction.
    • Dose variations (half or double) did not improve response.

    Conclusions:

    • A 45-minute constant intravenous infusion of CCK octapeptide is superior for gallbladder emptying.
    • This method provides more complete emptying, consistent responses, and no reported side effects compared to rapid injections.