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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Blood routine test-based biomarkers is related to bone mineral density in elderly patients with chronic heart
Insights
Blood routine test biomarkers correlate with bone mineral density in elderly heart failure patients. Hemoglobin and red blood cells are key indicators, particularly in early disease stages.
Area of Science:
- Gerontology
- Cardiology
- Biochemistry
Background:
- Previous research linked bone mineral density (BMD) to heart failure (HF) severity (NYHA classification).
- Blood routine test (BRT) biomarkers showed associations with BMD in the general population.
Purpose of the Study:
- To investigate the relationship between BRT biomarkers and BMD in elderly patients with chronic HF.
Main Methods:
- Retrospective study design.
- Simultaneous measurement of BRT and BMD.
- Statistical analyses included Chi-square, ANOVA, Wilcoxon rank-sum, and Spearman correlation tests.
Main Results:
- 1049 participants were analyzed.
- BRT biomarkers like hemoglobin and RBCs showed significant correlations with lumbar and femoral neck BMD.
- Hemoglobin's association with BMD was significant in NYHA class I and II HF patients.
Conclusions:
- BRT biomarkers exhibit significant differences across NYHA functional classes in chronic HF patients.
- These findings warrant further investigation for potential clinical applications.
Background:
Our previous studies suggested that bone mineral density (BMD) correlated with the severity of chronic heart failure (HF) as classified by the New York Heart Association (NYHA) and that blood routine test (BRT)-based biomarkers, including hemoglobin, red blood cells (RBCs), lymphocytes, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and systemic immune-inflammation index, were significantly related with BMD in general population.
Objective:
This work aimed to evaluate the relationship between BRT-based biomarkers and BMD in elderly patients with chronic HF.
Methods:
It was a retrospective study. BRT and BMD were measured on the same day. Chi-square analysis and 1-way analysis of variance or the Wilcoxon rank-sum test were used to compare categorical variables and continuous variables, respectively. Correlation analysis was performed by the Spearman correlation test.
Results:
A total of 1049 participants were enrolled. Hemoglobin, RBCs, white blood cells, neutrophils, monocytes, eosinophils, lymphocyte-to-monocyte ratio, and systemic immune-inflammation index were significantly different among different NYHA groups. The Spearman correlation test showed that lumbar vertebrae 2-4 (L2-L4) BMD was closely related to hemoglobin and RBC, and that femoral neck BMD was also significantly correlated with hemoglobin and RBC, white blood cells, neutrophils, monocytes, and platelets. Furthermore, stratified analysis in different NYHA classes demonstrated, only in NYHA class I and II groups, hemoglobin was significantly related to L2-L4 and femoral neck BMD.
Conclusion:
BRT-based biomarkers were significantly different among different NYHA groups, which deserves further investigation and application in the future.
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