Correlation of miRNAs with infarct volume in patients with acute ischemic stroke: A systematic review
Yanmeng Yang1, Guangming Wang2, Yanlong Tang1
1Radiology Department of the First Affiliated Hosptial of Dali University, Dali, Yunnan, China.
Background:
Rapid diagnosis of acute ischemic stroke (AIS) remains challenging, and reliable biomarkers are needed. MicroRNAs (miRNAs) are endogenous small noncoding regulatory RNA molecules present in the serum, plasma, and saliva. miRNAs are considered to be sensitive biomarkers of tissue damage because of their high stability and relative tissue specificity. The aim of this systematic review was to assess the correlation between miRNAs and infarct volume in patients with AIS, to provide a basis for predicting ischemic stroke onset and improving prognosis in the clinic, among others.
Methods:
From the search of published Chinese and English literature in PubMed, Cochrane Library, CNKI, VIP, and Wanfang databases up to July 1, 2023, we performed a descriptive summary of the included studies. And use of 12 quality evaluation items and Cochrane Risk of Bias tool to assess the quality of included studies.
Results:
This systematic review included 17 studies with articles involving 1443 cases were included in the data extraction for a total of 18 miRNA indicators. Among them, 9 indicators were positively associated with infarct volume in patients with AIS, including endothelial microvesicles-miR-155, miR-146b, miR-181c, miR-182, miR-34a, miR-92a, miR-122-5p, miR-451a, and miR-409-3P.
Conclusions:
This study shows that miRNA can be used as a biomarker for AIS, reflecting the severity of neurological deficits in this patient and providing a basis for clinical judgement of the patient's prognosis.
Insights
MicroRNAs (miRNAs) show promise as biomarkers for acute ischemic stroke (AIS). Certain miRNAs correlate with infarct volume, aiding in prognosis and clinical judgment for AIS patients.
Area of Science:
- Biochemistry
- Molecular Biology
- Neurology
Background:
- Acute ischemic stroke (AIS) diagnosis requires reliable biomarkers.
- MicroRNAs (miRNAs) are stable, tissue-specific RNA molecules found in bodily fluids.
- miRNAs show potential as sensitive indicators of tissue damage.
Purpose of the Study:
- To systematically review the correlation between miRNAs and infarct volume in AIS patients.
- To establish a basis for predicting stroke onset and improving clinical prognosis.
Main Methods:
- Systematic review of English and Chinese literature up to July 1, 2023.
- Searched databases: PubMed, Cochrane Library, CNKI, VIP, Wanfang.
- Assessed study quality using 12 items and Cochrane Risk of Bias tool.
Main Results:
- Included 17 studies with 1443 AIS cases and 18 miRNA indicators.
- Nine miRNA indicators showed a positive association with infarct volume.
- Specific miRNAs identified include miR-155, miR-146b, miR-181c, miR-182, miR-34a, miR-92a, miR-122-5p, miR-451a, and miR-409-3P.
Conclusions:
- miRNAs can serve as effective biomarkers for AIS.
- miRNA levels reflect neurological deficit severity in AIS patients.
- This provides a foundation for clinical prognosis assessment in AIS.
Related Concept Videos
01:15Ischemic Stroke l: Introduction
01:15Ischemic Stroke ll: Pathophysiology